Don't promise or imply lifetime employment

Consider other alternatives for cutting workforce costs

Consider other alternatives for cutting overall costs

Consider other ways to generate revenues

Be Honest with your Startup Team

Make sure your decisions are non-discriminatory

Inform Employees Privately

Consider Timing - Probably at the end of the work day

Prepare to console & count on bearing the brunt of some angry reactions

Offer Outplacement help

Negotiate a fair severance package.

In case of trouble, ensure the security of the rest of the work force and for corporate assets

Escort the employee(s) laid off to the exit of your Startup premises

Conduct a meeting with the rest of the Team

Avoid signs of extravagant spending following layoffs.